Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
Identifieur interne : 004F51 ( Main/Exploration ); précédent : 004F50; suivant : 004F52Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
Auteurs : Stefan Zeuzem [Allemagne] ; Tarik Asselah [France] ; Peter Angus [Australie] ; Jean-Pierre Zarski [France] ; Dominique Larrey [France] ; Beat Müllhaupt [Suisse] ; Ed Gane [Nouvelle-Zélande] ; Marcus Schuchmann [Allemagne] ; Ansgar W. Lohse [Allemagne] ; Stanislas Pol [France] ; Jean-Pierre Bronowicki [France] ; Stuart Roberts [Australie] ; Keikawus Arasteh [Allemagne] ; Fabien Zoulim [France] ; Markus Heim [Suisse] ; Jerry O. Stern [États-Unis] ; Gerhard Nehmiz [Allemagne] ; George Kukolj [Canada] ; Wulf O. Böcher [Allemagne] ; Federico J. Mensa [États-Unis]Source :
- Antiviral therapy : (London) [ 1359-6535 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib S0UND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods: Patients were randomized to receive deleobuvir 400 mg (n=15) or 600 mg (n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results: At week 4, 73% (11/15) and 100% (17/17) of patients in the deleobuvir 400 mg and 600 mg groups achieved HCV RNA<25 IU/ml. respectively. During interferon-free treatment, virological breakthrough was reported in one patient and re-increase of HCV RNA in one patient. Both patients were successfully treated with interferon-containing therapy. The rate of sustained virological response 24 weeks after completion of treatment was 73% (11/15) in the deleobuvir 400 mg group and 94% (16/17) in the 600 mg group. During faldaprevir plus pegylated interferon-α2a/ ribavirin treatment, the most common adverse events were pruritus (38% of patients), rash (31%) and asthenia (31%); these were severe in approximately 3% of patients. Conclusions: Potent antiviral activity and favourable safety of the treatment regimen were demonstrated. Furthermore, the results suggest that patients with breakthrough at week 4 may be rescued with an interferon-containing regimen.
Affiliations:
- Allemagne, Australie, Canada, France, Nouvelle-Zélande, Suisse, États-Unis
- Auvergne-Rhône-Alpes, Berlin, Canton de Zurich, District de Darmstadt, Grand Est, Hambourg, Hesse (Land), Languedoc-Roussillon, Lorraine (région), Occitanie (région administrative), Rhénanie-Palatinat, Rhône-Alpes, Île-de-France
- Berlin, Francfort-sur-le-Main, Grenoble, Hambourg, Lyon, Mayence, Montpellier, Nancy, Paris, Vandœuvre-lès-Nancy, Zurich
- Université Paris-Descartes
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Stern</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Boehringer Ingelheim Pharmaceuticals Inc.</s1><s2>Ridgefield, CT</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boehringer Ingelheim Pharmaceuticals Inc.</wicri:noRegion></affiliation></author><author><name sortKey="Nehmiz, Gerhard" sort="Nehmiz, Gerhard" uniqKey="Nehmiz G" first="Gerhard" last="Nehmiz">Gerhard Nehmiz</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Boehringer Ingelheim Pharma GmbH Et Co KG</s1><s2>Ingelheim</s2><s3>DEU</s3><sZ>17 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion></affiliation></author><author><name sortKey="Kukolj, George" sort="Kukolj, George" uniqKey="Kukolj G" first="George" last="Kukolj">George Kukolj</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Boehringer Ingelheim (Canada) Ltd</s1><s2>Laval, QC</s2><s3>CAN</s3><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Boehringer Ingelheim (Canada) Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Bocher, Wulf O" sort="Bocher, Wulf O" uniqKey="Bocher W" first="Wulf O." last="Böcher">Wulf O. Böcher</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Boehringer Ingelheim Pharma GmbH Et Co KG</s1><s2>Ingelheim</s2><s3>DEU</s3><sZ>17 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion></affiliation></author><author><name sortKey="Mensa, Federico J" sort="Mensa, Federico J" uniqKey="Mensa F" first="Federico J." last="Mensa">Federico J. Mensa</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Boehringer Ingelheim Pharmaceuticals Inc.</s1><s2>Ridgefield, CT</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boehringer Ingelheim Pharmaceuticals Inc.</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0057353</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 14-0057353 INIST</idno><idno type="RBID">Pascal:14-0057353</idno><idno type="wicri:Area/PascalFrancis/Corpus">000542</idno><idno type="wicri:Area/PascalFrancis/Curation">005916</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000954</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000954</idno><idno type="wicri:doubleKey">1359-6535:2013:Zeuzem S:faldaprevir:bi:deleobuvir</idno><idno type="wicri:Area/Main/Merge">005128</idno><idno 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wicri:level="1"><inist:fA14 i1="02"><s1>Service d'Hépatologie Hôpital Beaujon, Université Diderot-Paris 7, INSERM U773, CRB3</s1><s2>Clichy</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>CRB3</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Angus, Peter" sort="Angus, Peter" uniqKey="Angus P" first="Peter" last="Angus">Peter Angus</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Austin Hospital</s1><s2>Heidelberg, Victoria</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Austin Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Zarski, Jean Pierre" sort="Zarski, Jean Pierre" uniqKey="Zarski J" first="Jean-Pierre" last="Zarski">Jean-Pierre Zarski</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hôpital Albert Michallon</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Département d'Hépato-Gastroenterologie-CIC-IRB INSERM 1040, Hôpital Saint-Eloi</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>University Hospital of Zürich</s1><s2>Zürich</s2><s3>CHE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Gane, Ed" sort="Gane, Ed" uniqKey="Gane E" first="Ed" last="Gane">Ed Gane</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Auckland City Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>7 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland City Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Schuchmann, Marcus" sort="Schuchmann, Marcus" uniqKey="Schuchmann M" first="Marcus" last="Schuchmann">Marcus Schuchmann</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>University Medical Center Mainz</s1><s2>Mainz</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Lohse, Ansgar W" sort="Lohse, Ansgar W" uniqKey="Lohse A" first="Ansgar W." last="Lohse">Ansgar W. Lohse</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>University Hospital Hamburg-Eppendorf</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Université Paris Descartes, INSERM U1016 et APHP, Hôpital Cochin</s1><s2>Paris</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM U954, Centre Hospitalier Universitaire de Nancy, Université de Lorraine</s1><s2>Vandoeuvre-lès-Nancy</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Roberts, Stuart" sort="Roberts, Stuart" uniqKey="Roberts S" first="Stuart" last="Roberts">Stuart Roberts</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Alfred Hospital</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Alfred Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Arasteh, Keikawus" sort="Arasteh, Keikawus" uniqKey="Arasteh K" first="Keikawus" last="Arasteh">Keikawus Arasteh</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Epimed GmbH</s1><s2>Berlin</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Hepatology Department, Hospices Civils de Lyon, Lyon University</s1><s2>Lyon</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Heim, Markus" sort="Heim, Markus" uniqKey="Heim M" first="Markus" last="Heim">Markus Heim</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>University Hospital Basel</s1><s2>Basel</s2><s3>CHE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>University Hospital Basel</wicri:noRegion></affiliation></author><author><name sortKey="Stern, Jerry O" sort="Stern, Jerry O" uniqKey="Stern J" first="Jerry O." last="Stern">Jerry O. Stern</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Boehringer Ingelheim Pharmaceuticals Inc.</s1><s2>Ridgefield, CT</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boehringer Ingelheim Pharmaceuticals Inc.</wicri:noRegion></affiliation></author><author><name sortKey="Nehmiz, Gerhard" sort="Nehmiz, Gerhard" uniqKey="Nehmiz G" first="Gerhard" last="Nehmiz">Gerhard Nehmiz</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Boehringer Ingelheim Pharma GmbH Et Co KG</s1><s2>Ingelheim</s2><s3>DEU</s3><sZ>17 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion></affiliation></author><author><name sortKey="Kukolj, George" sort="Kukolj, George" uniqKey="Kukolj G" first="George" last="Kukolj">George Kukolj</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Boehringer Ingelheim (Canada) Ltd</s1><s2>Laval, QC</s2><s3>CAN</s3><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Boehringer Ingelheim (Canada) Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Bocher, Wulf O" sort="Bocher, Wulf O" uniqKey="Bocher W" first="Wulf O." last="Böcher">Wulf O. Böcher</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Boehringer Ingelheim Pharma GmbH Et Co KG</s1><s2>Ingelheim</s2><s3>DEU</s3><sZ>17 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion><wicri:noRegion>Boehringer Ingelheim Pharma GmbH Et Co KG</wicri:noRegion></affiliation></author><author><name sortKey="Mensa, Federico J" sort="Mensa, Federico J" uniqKey="Mensa F" first="Federico J." last="Mensa">Federico J. Mensa</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Boehringer Ingelheim Pharmaceuticals Inc.</s1><s2>Ridgefield, CT</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boehringer Ingelheim Pharmaceuticals Inc.</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term><term>Deleobuvir</term><term>Faldaprevir</term><term>Genotype</term><term>Hepatitis C virus</term><term>Oral administration</term><term>Result</term><term>Ribavirin</term><term>Typing</term><term>Viral hepatitis C</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ribavirine</term><term>Voie orale</term><term>Virus hépatite C</term><term>Génotype</term><term>Typage</term><term>Résultat</term><term>Antiviral</term><term>Hépatite virale C</term><term>Traitement initial</term><term>Faldaprévir</term><term>Déléobuvir</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib S0UND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods: Patients were randomized to receive deleobuvir 400 mg (n=15) or 600 mg (n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results: At week 4, 73% (11/15) and 100% (17/17) of patients in the deleobuvir 400 mg and 600 mg groups achieved HCV RNA<25 IU/ml. respectively. During interferon-free treatment, virological breakthrough was reported in one patient and re-increase of HCV RNA in one patient. Both patients were successfully treated with interferon-containing therapy. The rate of sustained virological response 24 weeks after completion of treatment was 73% (11/15) in the deleobuvir 400 mg group and 94% (16/17) in the 600 mg group. During faldaprevir plus pegylated interferon-α2a/ ribavirin treatment, the most common adverse events were pruritus (38% of patients), rash (31%) and asthenia (31%); these were severe in approximately 3% of patients. Conclusions: Potent antiviral activity and favourable safety of the treatment regimen were demonstrated. Furthermore, the results suggest that patients with breakthrough at week 4 may be rescued with an interferon-containing regimen.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Nouvelle-Zélande</li><li>Suisse</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Berlin</li><li>Canton de Zurich</li><li>District de Darmstadt</li><li>Grand Est</li><li>Hambourg</li><li>Hesse (Land)</li><li>Languedoc-Roussillon</li><li>Lorraine (région)</li><li>Occitanie (région administrative)</li><li>Rhénanie-Palatinat</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Francfort-sur-le-Main</li><li>Grenoble</li><li>Hambourg</li><li>Lyon</li><li>Mayence</li><li>Montpellier</li><li>Nancy</li><li>Paris</li><li>Vandœuvre-lès-Nancy</li><li>Zurich</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name></region><name sortKey="Arasteh, Keikawus" sort="Arasteh, Keikawus" uniqKey="Arasteh K" first="Keikawus" last="Arasteh">Keikawus Arasteh</name><name sortKey="Bocher, Wulf O" sort="Bocher, Wulf O" uniqKey="Bocher W" first="Wulf O." last="Böcher">Wulf O. Böcher</name><name sortKey="Lohse, Ansgar W" sort="Lohse, Ansgar W" uniqKey="Lohse A" first="Ansgar W." last="Lohse">Ansgar W. Lohse</name><name sortKey="Nehmiz, Gerhard" sort="Nehmiz, Gerhard" uniqKey="Nehmiz G" first="Gerhard" last="Nehmiz">Gerhard Nehmiz</name><name sortKey="Schuchmann, Marcus" sort="Schuchmann, Marcus" uniqKey="Schuchmann M" first="Marcus" last="Schuchmann">Marcus Schuchmann</name></country><country name="France"><noRegion><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name></noRegion><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><name sortKey="Zarski, Jean Pierre" sort="Zarski, Jean Pierre" uniqKey="Zarski J" first="Jean-Pierre" last="Zarski">Jean-Pierre Zarski</name><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name></country><country name="Australie"><noRegion><name sortKey="Angus, Peter" sort="Angus, Peter" uniqKey="Angus P" first="Peter" last="Angus">Peter Angus</name></noRegion><name sortKey="Roberts, Stuart" sort="Roberts, Stuart" uniqKey="Roberts S" first="Stuart" last="Roberts">Stuart Roberts</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name></region><name sortKey="Heim, Markus" sort="Heim, Markus" uniqKey="Heim M" first="Markus" last="Heim">Markus Heim</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Gane, Ed" sort="Gane, Ed" uniqKey="Gane E" first="Ed" last="Gane">Ed Gane</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Stern, Jerry O" sort="Stern, Jerry O" uniqKey="Stern J" first="Jerry O." last="Stern">Jerry O. Stern</name></noRegion><name sortKey="Mensa, Federico J" sort="Mensa, Federico J" uniqKey="Mensa F" first="Federico J." last="Mensa">Federico J. Mensa</name></country><country name="Canada"><noRegion><name sortKey="Kukolj, George" sort="Kukolj, George" uniqKey="Kukolj G" first="George" last="Kukolj">George Kukolj</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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